I will copy a few interesting quotes here from different sites: "The ECS appears to be one of the most integral bodily systems for regulating our health and well-being (and many lifeforms before us on the evolutionary spectrum, even nematodes!). [...] Research demonstrates that even small doses of CBD stimulate your body to produce more endocannabinoids, like anandamide and 2-AG, and create new cannabinoid receptors. [...] Two key endocannabinoids are 2-arachidonoylglycerol (2-AG) and anandamide. 2-AG and anandamide are derivatives of the essential omega-6 fatty acid known as arachidonic acid; these endocannabinoids are produced as necessary for producing local healing and restorative effects in target tissues before being deactivated by enzymes. [...] The better options for boosting levels of anandamide is to eat foods containing arachidonic acid, such as meat and eggs, or to supplement with arachidonic acid directly." (From AnxietyHack) "Low levels of omega-6 fats with pyroluria appear to result from a problem with the production of arachidonic acid (AA). This is different from the mechanism behind low vitamin B6 and zinc in high mauve. HPL depletes zinc and B6 by binding to these nutrients, which causes them to be excreted in urine. So it’s not that the omega-6 arachidonic acid is depleted in pyroluria, it’s that its synthesis is inhibited. This block in AA synthesis appears to result from a problem with delta-6-desaturase, the enzyme which converts the omega-6 precursor linoleic acid into gamma-linoleic acid (GLA), which is then converted into AA. This same enzyme is also required for the synthesis of omega-3 fatty acids, so both omega-3 and -6 PUFA synthesis may be inhibited, but it appears that with high mauve, it’s more common for just the omega-6 eicosanoids to be affected. [...] Both zinc and B6 are cofactors required for the proper function of delta-6-desaturase (6) (7). Reduced omega-6 fatty acid levels may therefore be a secondary deficiency resulting from low zinc and B6. [...] Chronic viral infections may also decrease D6D activity in both the omega-3 and omega-6 pathways." (From LivingLoveCommunity) Same old question, what was first? Does Pyroluria increase toxicity by inhibiting the endocannabinoid system and lack of nutrients, or is Pyroluria a symptom of mercury toxicity since mercury inhibits lots of enzymes and is a neurotoxin in the first place. I have heard of people who reversed their pyroluria by detoxing the heavy metals. Few videos about the connection of the endocannabinoid system and autism: Apparently CBD Oil can be a good treatment for autism:
"The study was led by the director of pediatric neurology at Jerusalem’s Shaare Zedek Hospital, Dr. Adi Aran, who treated the 60 children with a high-CBD cannabis oil (20% CBD and 1% THC). The children were treated for at least seven months with the oil. After the treatment period, parents answered assessment questionnaires to characterize their child’s condition. Questions were asked about behavioral changes, anxiety levels and ability to communicate. Here’s what they reported:
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